Hydrochloric Acid → 4-Bromo-2,3-dihydro-1H-inden-1-ol

HRID 234078

반응식

HRID 234078 반응식
[Br:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH2:4][CH2:5][C:6]2=[O:11].[BH4-].[Na+].Cl>C(O)C.O1CCCC1>[Br:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH2:4][CH2:5][CH:6]2[OH:11]

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 987131-Indanone, 4-bromo-HCID 4311764Sodium borohydride

생성물 1

HCID 133302084-Bromo-2,3-dihydro-1H-inden-1-ol

시약·촉매·용매 2

HCID 702Ethanol용매HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 4-bromo-1-indanone (1.0 g) in a mixture of ethanol (6 ml) and tetrahydrofuran (3 ml) was added sodium borohydride (0.09 g) at an ice temperature. The reaction mixture was stirred at the same temperature overnight and poured into dilute hydrochloric acid, and the aqueous layer was saturated with saline and extracted with ether. The organic layer was washed with a saturated aqueous saline, dried over sodium sulfate, and the solvent was removed by distillation under reduced pressure. The residual concentrate (1.02 g) thus obtained was used for the next reaction without further purification.

후처리

  1. extractionextracted with ether
  2. washThe organic layer was washed with a saturated aqueous saline
  3. dry with materialdried over sodium sulfate
  4. customthe solvent was removed by distillation under reduced pressure
  5. concentrationThe residual concentrate (1.02 g)
  6. customthus obtained
  7. customwas used for the next reaction without further purification

출처 및 근거

ORD 기록
ord-01f71f65fdf84ea39e9ca101f8c5f389
출처 데이터셋
uspto-grants-1997_01
특허 번호
US05594081

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