Azobisisobutyronitrile → 4-(Bromomethyl)-2-chloro-1-iodobenzene

HRID 234766노트

반응식

HRID 234766 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH3:9])[CH:5]=[CH:6][C:7]=1[I:8].[Br:10]N1C(=O)CCC1=O.N(C(C)(C)C#N)=NC(C)(C)C#N>C(Cl)(Cl)(Cl)Cl>[Cl:1][C:2]1[CH:3]=[C:4]([CH:5]=[CH:6][C:7]=1[I:8])[CH2:9][Br:10]

참가 물질

5

반응물 3

HCID 6547AzobisisobutyronitrileHCID 67184N-bromobutanimideHCID 27576182-Chloro-1-iodo-4-methylbenzene

생성물 1

HCID 542552924-(Bromomethyl)-2-chloro-1-iodobenzene

시약·촉매·용매 1

HCID 5943Carbon Tetrachloride용매

실험 절차

A suspension of 40.4 g (160 mmol) of the compound from Example XXXI in 400 ml of carbon tetrachloride, 31.3 g of N-bromosuccinimide (176 mmol) and 2.63 g of azobisisobutyronitrile (16 mmol) is heated under reflux overnight. After cooling, the precipitate is filtered off with suction and washed with carbon tetrachloride. The combined filtrates are concentrated and the residue is further reacted in the crude state.

후처리

  1. temperatureis heated
  2. temperatureunder reflux overnight
  3. temperatureAfter cooling
  4. filtrationthe precipitate is filtered off with suction
  5. washwashed with carbon tetrachloride
  6. concentrationThe combined filtrates are concentrated
  7. customthe residue is further reacted in the crude state

출처 및 근거

ORD 기록
ord-2d9396fe463b42afb56f4077c7234a30
출처 데이터셋
uspto-grants-1997_01
특허 번호
US05596006

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