Bromine → 5-Isopropyl-2-nitro-4-thiocyanato-phenylamine
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[CH:1]([C:4]1[CH:5]=[CH:6][C:7]([N+:11]([O-:13])=[O:12])=[C:8]([NH2:10])[CH:9]=1)([CH3:3])[CH3:2].[S-:14][C:15]#[N:16].[Na+].[Br-].[Na+].BrBr>CO>[CH:1]([C:4]1[C:5]([S:14][C:15]#[N:16])=[CH:6][C:7]([N+:11]([O-:13])=[O:12])=[C:8]([NH2:10])[CH:9]=1)([CH3:3])[CH3:2]참가 물질
6
실험 절차
The title compound was prepared according to General Method 13 using 5-isopropyl-2-nitro-phenylamine (prepared in Example PP-1; 5.4 g, 30 mmol), sodium thiocyanate (14.6 g, 180 mmol), sodium bromide (3.7 g, 35.99 mmol), bromine (5.75 g, 36.0 mmol), and MeOH (100 mL). The crude reaction mixture was purified by flash silica gel chromatography (5%-50% EtOAc in hexanes as eluents). MS(APCI): 238 (M+H).
후처리
- customThe crude reaction mixture
- customwas purified by flash silica gel chromatography (5%-50% EtOAc in hexanes as eluents)
출처 및 근거
- ORD 기록
- ord-233cc62428524c4396e8779a88af5ae1
- 출처 데이터셋
- uspto-grants-2005_02
- 특허 번호
- US06852711B2
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