Bromine → 5-Isopropyl-2-nitro-4-thiocyanato-phenylamine

HRID 23484

반응식

HRID 23484 반응식
[CH:1]([C:4]1[CH:5]=[CH:6][C:7]([N+:11]([O-:13])=[O:12])=[C:8]([NH2:10])[CH:9]=1)([CH3:3])[CH3:2].[S-:14][C:15]#[N:16].[Na+].[Br-].[Na+].BrBr>CO>[CH:1]([C:4]1[C:5]([S:14][C:15]#[N:16])=[CH:6][C:7]([N+:11]([O-:13])=[O:12])=[C:8]([NH2:10])[CH:9]=1)([CH3:3])[CH3:2]

참가 물질

6

반응물 4

HCID 24408BromineHCID 253881Sodium BromideHCID 516871Sodium thiocyanateHCID 225728525-Isopropyl-2-nitroaniline

생성물 1

HCID 225729135-Isopropyl-2-nitro-4-thiocyanato-phenylamine

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

The title compound was prepared according to General Method 13 using 5-isopropyl-2-nitro-phenylamine (prepared in Example PP-1; 5.4 g, 30 mmol), sodium thiocyanate (14.6 g, 180 mmol), sodium bromide (3.7 g, 35.99 mmol), bromine (5.75 g, 36.0 mmol), and MeOH (100 mL). The crude reaction mixture was purified by flash silica gel chromatography (5%-50% EtOAc in hexanes as eluents). MS(APCI): 238 (M+H).

후처리

  1. customThe crude reaction mixture
  2. customwas purified by flash silica gel chromatography (5%-50% EtOAc in hexanes as eluents)

출처 및 근거

ORD 기록
ord-233cc62428524c4396e8779a88af5ae1
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06852711B2

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