Dimethylformamide → 5-Ethyl-2-furaldehyde

HRID 235108

반응식

HRID 235108 반응식
CN([CH:4]=[O:5])C.O=P(Cl)(Cl)Cl.[CH2:11]([C:13]1[O:14][CH:15]=[CH:16][CH:17]=1)[CH3:12]>>[CH2:11]([C:13]1[O:14][C:15]([CH:4]=[O:5])=[CH:16][CH:17]=1)[CH3:12]

참가 물질

4

반응물 3

HCID 6228DimethylformamideHCID 185542-EthylfuranHCID 24813Phosphorus oxychloride

생성물 1

HCID 899895-Ethyl-2-furaldehyde수율 68.9%

반응 조건

온도
0 °C

실험 절차

A sample of DMF (9.3 mL, 120 mmol) was cooled to 0° C. and POCl3 (3.37 g, 22 mmol) was added, the mixture was stirred for 1 hour at 0° C., then 2-ethyl furan (1.92 g, 20 mmol) was added. The reaction was quenched by pouring onto ice, and the mixture was stirred for 18 hours. The mixture was extracted with hexane, which was dried over MgSO4 and concentrated to give 1.71 g of the title compound (used without further purification).

후처리

  1. customThe reaction was quenched
  2. additionby pouring onto ice
  3. stirringthe mixture was stirred for 18 hours
  4. extractionThe mixture was extracted with hexane, which
  5. dry with materialwas dried over MgSO4
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-8d178fb4c5434ea987c1f70c41398c35
출처 데이터셋
uspto-grants-1997_01
특허 번호
US05597832

연결된 노트

불러오는 중…