Methanol → Methyl 2,3-dihydro-1H-pyrrolizine-1-carboxylate

HRID 2352037

반응식

HRID 2352037 반응식
[CH:1]1([C:9]([OH:11])=[O:10])[CH2:5][CH2:4][N:3]2[CH:6]=[CH:7][CH:8]=[C:2]12.[CH3:12]O>Cl>[CH:1]1([C:9]([O:11][CH3:12])=[O:10])[CH2:5][CH2:4][N:3]2[CH:6]=[CH:7][CH:8]=[C:2]12

참가 물질

4

반응물 2

HCID 887MethanolHCID 127951052,3-Dihydro-1h-pyrrolizine-1-carboxylic acid

생성물 1

HCID 12795075Methyl 2,3-dihydro-1H-pyrrolizine-1-carboxylate

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

2,3-Dihydro-1H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid is dissolved in methanol containing a small amount of concentrated hydrochloric acid. The resulting solution is heated to reflux, and then cooled. The title compound is isolated by rotary evaporation of the solvent under reduced pressure, and may be purified by chromatography on silica gel with hexane/ethyl acetate as eluent.

후처리

  1. temperatureThe resulting solution is heated
  2. temperatureto reflux
  3. temperaturecooled

출처 및 근거

ORD 기록
ord-586d422b14554575a5537722250183b1
출처 데이터셋
uspto-grants-1989_10
특허 번호
US04874871

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