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Hydrochloric Acid → 2-ethyl-N-[4-[[3-(hydroxymethylidene)-2-oxo-1H-indol-5-yl]methyl]phenyl]-5-methylpyrazole-3-carboxamide

HRID 2352781
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HRID 2352781 반응식
[O:1]=[C:2]1[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([CH2:11][C:12]3[CH:17]=[CH:16][C:15]([NH:18][C:19]([C:21]4[N:22]([CH2:27][CH3:28])[N:23]=[C:24]([CH3:26])[CH:25]=4)=[O:20])=[CH:14][CH:13]=3)[CH:8]=2)[NH:3]1.[CH:29](OCC)=[O:30].[O-]CC.[Na+].Cl>C(O)C>[OH:30][CH:29]=[C:10]1[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([CH2:11][C:12]3[CH:13]=[CH:14][C:15]([NH:18][C:19]([C:21]4[N:22]([CH2:27][CH3:28])[N:23]=[C:24]([CH3:26])[CH:25]=4)=[O:20])=[CH:16][CH:17]=3)[CH:8]=2)[NH:3][C:2]1=[O:1]
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참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 8025Ethyl formateHCID 2723922Sodium ethoxideHCID 866103752-Ethyl-5-methyl-2H-pyrazole-3-carboxylic acid [4-(2-oxo-2,3-dihydro-1H-indol-5-ylmethyl)-phenyl]-amide

생성물 1

HCID 1784630622-ethyl-N-[4-[[3-(hydroxymethylidene)-2-oxo-1H-indol-5-yl]methyl]phenyl]-5-methylpyrazole-3-carboxamide수율 47%

시약·촉매·용매

1
HCID 702Ethanol용매2회

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온도
78 °C

실험 절차

2-Ethyl-5-methyl-2H-pyrazole-3-carboxylic acid [4-(2-oxo-2,3-dihydro-1H-indol-5-ylmethyl)-phenyl]-amide (0.140 g, 0.374 mmol) and ethyl formate (0.060 mL, 0.816 mmol) were dissolved in anhydrous ethanol (0.250 mL). The resulting solution was treated in dropwise fashion with a 21 wt % solution of sodium ethoxide in ethanol (0.42 mL, 1.12 mmol). This reaction mixture was heated at 78° C. for 0.5-1 h, producing a viscous, dark reddish colored oil. Subsequently, the reaction mixture was cooled to room temperature, and then the reaction pH was adjusted to pH 3 with dropwise addition of 1M HCl(aq) causing the formation of a grey precipitate. The suspension was filtered yielding a grey solid as the pure product (0.070 g, 0.175 mmol, 47%).

후처리

  1. customproducing a viscous, dark reddish colored oil
  2. temperatureSubsequently, the reaction mixture was cooled to room temperature
  3. filtrationThe suspension was filtered

출처 및 근거

ORD 기록
ord-e63f3380b8dc4a3a9de0082715bfda43
출처 데이터셋
uspto-grants-2010_07
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07749530B2

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