Methanol → 4-(3-tert-Butyl-4-methoxybenzoyloxyethyl)benzenemethanol

HRID 235319

반응식

HRID 235319 반응식
[C:1]([C:5]1[CH:6]=[C:7]([CH:20]=[CH:21][C:22]=1[O:23][CH3:24])[C:8]([O:10][CH2:11]C1C=CC(C=O)=CC=1)=[O:9])([CH3:4])([CH3:3])[CH3:2].[CH2:25]1[CH2:29][O:28][CH2:27][CH2:26]1.CO.[BH4-].[Na+]>O>[C:1]([C:5]1[CH:6]=[C:7]([CH:20]=[CH:21][C:22]=1[O:23][CH3:24])[C:8]([O:10][CH2:11][CH2:22][C:5]1[CH:27]=[CH:26][C:25]([CH2:29][OH:28])=[CH:2][CH:1]=1)=[O:9])([CH3:3])([CH3:4])[CH3:2]

참가 물질

6

반응물 4

HCID 887MethanolHCID 8028TetrahydrofuranHCID 4311764Sodium borohydrideHCID 214745254-(3-tert-Butyl-4-methoxybenzoyloxymethyl)benzaldehyde

생성물 1

HCID 538480554-(3-tert-Butyl-4-methoxybenzoyloxyethyl)benzenemethanol

시약·촉매·용매 1

HCID 962Water용매

실험 절차

1.6 g (5 mmol) of the aldehyde obtained in Example 45, 50 ml of THF and 50 ml of methanol are introduced into a round-bottomed flask. 100 mg (2.5 mmol) of sodium borohydride are added in small portions and the mixture is stirred at room temperature for 4 h. The reaction medium is poured into water, the mixture is extracted with ethyl ether and the organic phase is separated after settling has taken place, dried over magnesium sulphate and evaporated.

후처리

  1. extractionthe mixture is extracted with ethyl ether
  2. customthe organic phase is separated after settling
  3. dry with materialdried over magnesium sulphate
  4. customevaporated

출처 및 근거

ORD 기록
ord-9f4bd2205b2e42ceba968bdc02156d6e
출처 데이터셋
uspto-grants-1997_01
특허 번호
US05597839

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