2-Aminothiazole → tert-butyl N-[(2-methylpropan-2-yl)oxycarbonyl]-N-(1,3-thiazol-2-yl)carbamate
반응식
[NH2:1][C:2]1[S:3][CH:4]=[CH:5][N:6]=1.C(=O)(OC(C)(C)C)[O:8][C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=O>CN(C1C=CN=CC=1)C.C1COCC1>[CH3:15][C:12]([O:11][C:9]([N:1]([C:2]1[S:3][CH:4]=[CH:5][N:6]=1)[C:9](=[O:8])[O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:8])([CH3:13])[CH3:14]참가 물질
5
실험 절차
A solution of 2-aminothiazole (5 g, 0.05 mol), (2-methylpropan-2-yl)oxycarbonyl tert-butyl carbonate (27.8 g, 0.15 mol) and DMAP (100 mg) in THF (100 mL) was stirred at reflux overnight. The mixture was allowed to cool and concentrated in vacuo. The residue was chromatographed on silica, eluting with 8% ethyl acetate in hexane, to give the desired material as a white solid (12 g).
후처리
- temperatureat reflux overnight
- temperatureto cool
- concentrationconcentrated in vacuo
- customThe residue was chromatographed on silica
- washeluting with 8% ethyl acetate in hexane
출처 및 근거
- ORD 기록
- ord-457ab25f55914f61a52cbae8174eabb4
- 출처 데이터셋
- uspto-grants-2010_07
- 특허 번호
- US07750003B2
반응 노트
불러오는 중…