Acetovanillone → 4-Ethylguaiacol
반응식
[CH3:1][C:2]([C:4]1[CH:12]=[CH:11][C:9]([OH:10])=[C:6]([O:7][CH3:8])[CH:5]=1)=O>C(O)C.[Pd].Cl>[CH2:2]([C:4]1[CH:12]=[CH:11][C:9]([OH:10])=[C:6]([O:7][CH3:8])[CH:5]=1)[CH3:1]참가 물질
5
실험 절차
Acetovanillone (Aldrich, 11.0 g, 66 mmol) was dissolved in absolute ethanol (200 ml) and added to 1.5 g of 5% palladium on carbon. A few drops of concentrated hydrochloric acid were added and the mixture hydrogenated on a shaker at 42 psi. The reaction mixture was filtered through Celite, and the filtrate was concentrated to afford 10.3 g of a golden liquid. This was diluted with water, extracted with diethyl ether and the organic phase was washed with water and sodium bicarbonate. The solvent was dried (MgSO4) and concentrated to afford 9.3 g of a slightly yellow liquid.
후처리
- filtrationThe reaction mixture was filtered through Celite
- concentrationthe filtrate was concentrated
출처 및 근거
- ORD 기록
- ord-df0e2d250203424994510b8134c015e4
- 출처 데이터셋
- uspto-grants-1997_01
- 특허 번호
- US05597842
반응 노트
불러오는 중…