p-Chlorothiophenol → 2-[(4-Chlorophenyl)thio]ethanamine
반응식
[Na].Br.Br[CH2:4][CH2:5][NH2:6].[Cl:7][C:8]1[CH:13]=[CH:12][C:11]([SH:14])=[CH:10][CH:9]=1>C(O)C>[Cl:7][C:8]1[CH:13]=[CH:12][C:11]([S:14][CH2:4][CH2:5][NH2:6])=[CH:10][CH:9]=1참가 물질
5
반응 조건
- 온도
- 75 °C
실험 절차
A solution of sodium metal (22.5 mg, 0.98 mmol) in ethanol (2.0 mL) was treated with 2-bromoethylamine hydrobromide (100.0 mg, 0.49 mmol) and 4-chlorobenzenethiol (71.0 mg, 0.49 mmol), heated to 75° C. for 18 hours, and concentrated. The concentrate was partitioned between water (2.0 mL) and diethyl ether (5.0 mL) and the organic phase was dried (MgSO4), filtered, and concentrated to provide the desired product. MS (DCI) m/e 188 (M+H)+.
후처리
- concentrationconcentrated
- customThe concentrate was partitioned between water (2.0 mL) and diethyl ether (5.0 mL)
- dry with materialthe organic phase was dried (MgSO4)
- filtrationfiltered
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-e19874b790974d4abc4aac9364f5c8ae
- 출처 데이터셋
- uspto-grants-2010_07
- 특허 번호
- US07754886B2
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