Phosphorus tribromide → HCID 22730382, 화합물

HRID 2356143노트

반응식

HRID 2356143 반응식
O[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([O:17][CH3:18])=[O:16])=[CH:11][CH:10]=2)=[C:5]([O:19][CH3:20])[CH:4]=1.[Li+].[Br-].P(Br)(Br)[Br:24]>CN(C=O)C>[Br:24][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([O:17][CH3:18])=[O:16])=[CH:11][CH:10]=2)=[C:5]([O:19][CH3:20])[CH:4]=1

참가 물질

5

반응물 3

HCID 24614Phosphorus tribromideHCID 82050Lithium BromideHCID 22730788HCID 22730788, 화합물

생성물 1

HCID 22730382HCID 22730382, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A solution of Example 417A (1.50 g, 5.51 mmol) in DMF (18.0 mL) at 0° C. was treated with LiBr (526 mg, 6.06 mmol) and PBr3 (1.64 g, 6.06 mmol), warmed to room temperature, and stirred for 30 minutes. The solution was purified by flash column chromatography on silica gel with 3:7 ethyl acetate/hexanes to provide the desired product.

후처리

  1. customThe solution was purified by flash column chromatography on silica gel with 3:7 ethyl acetate/hexanes

출처 및 근거

ORD 기록
ord-a28e6b8e34d14c0687018ecbca7567d0
출처 데이터셋
uspto-grants-2010_07
특허 번호
US07754886B2

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