Acrylamide → 3-(Piperidin-1-yl)propanamide

HRID 235670

반응식

HRID 235670 반응식
[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[C:7]([NH2:11])(=[O:10])[CH:8]=[CH2:9]>CCO>[O:10]([CH2:6][CH2:5][CH3:4])[CH2:7][CH2:8][CH3:9].[N:1]1([CH2:9][CH2:8][C:7]([NH2:11])=[O:10])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

5

반응물 2

HCID 6579AcrylamideHCID 8082Piperidine

생성물 2

HCID 8114Propyl etherHCID 5667843-(Piperidin-1-yl)propanamide수율 75%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of piperidine, 4-(diphenylmethylene) (0.10 mole) and acrylamide (8.95 g, 0.062 mole) in EtOH (50 ml) was refluxed overnight. This reaction mixture was filtered and concentrated. The resulting while solid residue was dissolved in CHCl3, washed with H2O (3×150 ml), dried (Na2SO4) and the solvent removed to give thick yellow oil. Crystallization from CH2Cl2 --i--Pr2O afforded 29.01 g (75%) of 1-piperidinepropanamide, 4-(diphenylmethylene)-; mp 105°-7° C.

후처리

  1. filtrationThis reaction mixture was filtered
  2. concentrationconcentrated
  3. dissolutionThe resulting while solid residue was dissolved in CHCl3
  4. washwashed with H2O (3×150 ml)
  5. dry with materialdried (Na2SO4)
  6. customthe solvent removed
  7. customto give thick yellow oil
  8. customCrystallization from CH2Cl2

출처 및 근거

ORD 기록
ord-41cfecc7b47843609ffcb8f699a8479d
출처 데이터셋
uspto-grants-1987_02
특허 번호
US04640925

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