Hydrochloric Acid → n-[5-(4,4-Dimethyl-2,5-dioxo-3-pyridin-4-ylmethyl-imidazolidin-1-yl)-2-isopropyl-phenyl]-2-chloro-acetamide

HRID 2356942노트

반응식

HRID 2356942 반응식
[NH2:1][C:2]1[CH:3]=[C:4]([N:11]2[C:15](=[O:16])[C:14]([CH3:18])([CH3:17])[N:13]([CH2:19][C:20]3[CH:25]=[CH:24][N:23]=[CH:22][CH:21]=3)[C:12]2=[O:26])[CH:5]=[CH:6][C:7]=1[CH:8]([CH3:10])[CH3:9].CCN(C(C)C)C(C)C.[Cl:36][CH2:37][C:38](Cl)=[O:39].Cl>ClCCCl>[CH3:18][C:14]1([CH3:17])[C:15](=[O:16])[N:11]([C:4]2[CH:5]=[CH:6][C:7]([CH:8]([CH3:9])[CH3:10])=[C:2]([NH:1][C:38](=[O:39])[CH2:37][Cl:36])[CH:3]=2)[C:12](=[O:26])[N:13]1[CH2:19][C:20]1[CH:21]=[CH:22][N:23]=[CH:24][CH:25]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 6577Chloroacetyl chlorideHCID 81531DiisopropylethylamineHCID 115304483-(3-Amino-4-isopropyl-phenyl)-5,5-dimethyl-1-pyridin-4-ylmethyl-imidazolidine-2,4-dione

생성물 1

HCID 23110307n-[5-(4,4-Dimethyl-2,5-dioxo-3-pyridin-4-ylmethyl-imidazolidin-1-yl)-2-isopropyl-phenyl]-2-chloro-acetamide

시약·촉매·용매 1

HCID 111,2-Dichloroethane용매2회

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온도
-20 °C

실험 절차

1.37 mg (3.89 mmol) 3-(3-amino-4-isopropyl-phenyl)-5,5-dimethyl-1-pyridin-4-ylmethyl-imidazolidine-2,4-dione and 528 mg (4.08 mmol) Hünig's base were dissolved in 50 ml 1,2-dichloroethane. The mixture was cooled to −20° C. and treated with a solution of 439 mg (3.89 mmol) chloroacetylchlorid in 20 ml 1,2-dichloroethane. After stirring 1 h at 0° C., 25 ml ethanolic hydrochloric acid were added and the mixture evaporated to dryness. The raw material, containing huening's base hydrochloride was used without further purification.

후처리

  1. customthe mixture evaporated to dryness
  2. additionThe raw material, containing huening's base hydrochloride
  3. customwas used without further purification

출처 및 근거

ORD 기록
ord-1a9e51d6e0f94d7f973c7cf5930e1bdb
출처 데이터셋
uspto-grants-2010_07
특허 번호
US07759379B2

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