Diethyl Carbonate → HCID 68637486, 화합물

HRID 2357871노트

반응식

HRID 2357871 반응식
[F:1][C:2]1[C:7]([F:8])=[CH:6][C:5]([F:9])=[CH:4][C:3]=1[CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12].[CH2:16]([O:18][C:19](=O)[O:20]CC)[CH3:17].[H-].[Na+]>C1(C)C=CC=CC=1>[CH2:14]([O:13][C:11](=[O:12])[CH:10]([C:3]1[CH:4]=[C:5]([F:9])[CH:6]=[C:7]([F:8])[C:2]=1[F:1])[C:19]([O:18][CH2:16][CH3:17])=[O:20])[CH3:15]

참가 물질

5

반응물 3

HCID 7766Diethyl CarbonateHCID 24758Sodium hydrideHCID 53419349Benzoic acid, 2,3,5-trifluoro-, ethyl ester

생성물 1

HCID 68637486HCID 68637486, 화합물수율 82.9%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

Ethyl 2-(2,3,5-trifluorophenyl)-acetate (29 g) was slowly added to a mixture of diethylcarbonate (63 g) and sodium hydride (9.5 g) in toluene (350 ml). After being refluxed for 3 hours, the reaction mixture was cooled, treated with ice-water and washed with water. The organic layer was separated, dried and filtered. The filtrate was concentrated in vacuo to yield 32 g of the title compound.

후처리

  1. temperatureAfter being refluxed for 3 hours
  2. temperaturethe reaction mixture was cooled
  3. washwashed with water
  4. customThe organic layer was separated
  5. customdried
  6. filtrationfiltered
  7. concentrationThe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-b4adab8be14a42df801d63a3755c957b
출처 데이터셋
uspto-grants-2010_07
특허 번호
US07763622B2

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