Ethyl 2-nitro-4-benzoylphenylacetate → Ethyl 2-amino-4-benzoylphenylacetate

HRID 236372

반응식

HRID 236372 반응식
[N+:1]([C:4]1[CH:9]=[C:8]([C:10](=[O:17])[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:7]=[CH:6][C:5]=1[CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])([O-])=O>[Ni].C(O)C>[NH2:1][C:4]1[CH:9]=[C:8]([C:10](=[O:17])[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:7]=[CH:6][C:5]=1[CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20]

참가 물질

4

반응물 1

HCID 13770535Ethyl 2-nitro-4-benzoylphenylacetate

생성물 1

HCID 13770537Ethyl 2-amino-4-benzoylphenylacetate

시약·촉매·용매 2

HCID 935Nickel촉매HCID 702Ethanol용매

실험 절차

To a solution of 14 g. (44.7 mmoles) of ethyl 2-nitro-4-benzoylphenylacetate in 225 ml. of ethanol was added 15 g. of wet Raney nickel and the mixture heated to reflux for 1.5 hours. The mixture was filtered and the filtrate concentrated to give a residual oil which was induced to crystallize by trituration with diethyl ether, 7.9 g., m.p. 150°-152° C.

후처리

  1. temperatureto reflux for 1.5 hours
  2. filtrationThe mixture was filtered
  3. concentrationthe filtrate concentrated
  4. customto give a residual oil which
  5. customto crystallize by trituration with diethyl ether, 7.9 g

출처 및 근거

ORD 기록
ord-1236173910b142118fc888e02d448121
출처 데이터셋
uspto-grants-1987_02
특허 번호
US04644005

연결된 노트

불러오는 중…