Hydrochloric Acid → HCID 59625999, 화합물

HRID 2365287노트

반응식

HRID 2365287 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[N:7]1[CH2:16][CH2:15][C:14]2[C:9](=[C:10]([C:17]([O:19]C)=[O:18])[CH:11]=[CH:12][CH:13]=2)[CH2:8]1.[OH-].[Na+].Cl>C1COCC1>[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[N:7]1[CH2:16][CH2:15][C:14]2[C:9](=[C:10]([C:17]([OH:19])=[O:18])[CH:11]=[CH:12][CH:13]=2)[CH2:8]1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 59625970HCID 59625970, 화합물

생성물 1

HCID 59625999HCID 59625999, 화합물수율 311.6%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Compound 9u (187 mg, 0.44 mmol) was refluxed with 3N aqueous NaOH (0.25 mL mg, 0.75 mmol) in THF (6 mL) overnight. Concentrated HCl solution was added to the mixture to adjust pH to 3-4. The resulting mixture was concentrated to give 9v (350 mg) as the tris-HCl salt.

후처리

  1. concentrationThe resulting mixture was concentrated

출처 및 근거

ORD 기록
ord-2c709c7d41544538a9771d61759fb130
출처 데이터셋
uspto-grants-2014_04
특허 번호
US08697684B2

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