Acetic Acid → 1-(4-Hydroxybenzyl)-1,2,3,6-tetrahydropyridine hydrochloride

HRID 236556노트

반응식

HRID 236556 반응식
C([O:9][C:10]1[CH:22]=[CH:21][C:13]([CH2:14][N:15]2[CH2:20][CH:19]=[CH:18][CH2:17][CH2:16]2)=[CH:12][CH:11]=1)(=O)C1C=CC=CC=1.[OH-].[Na+].C(O)(=O)C.[ClH:29]>C(O)C.O>[ClH:29].[OH:9][C:10]1[CH:22]=[CH:21][C:13]([CH2:14][N:15]2[CH2:16][CH:17]=[CH:18][CH2:19][CH2:20]2)=[CH:12][CH:11]=1

참가 물질

7

반응물 4

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 202161341-(4-Benzoyloxybenzyl)-1,2,3,6-tetrahydropyridine

생성물 1

HCID 202161261-(4-Hydroxybenzyl)-1,2,3,6-tetrahydropyridine hydrochloride

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

A solution of 1-(4-benzoyloxybenzyl)-1,2,3,6-tetrahydropyridine (1.0 g.) in ethanol (15 ml.) and water (5 ml.) containing sodium hydroxide (0.245 g.) was stirred for 2.5 hours. Ice-water (35 ml.) was added followed by acetic acid to pH7. The solid which formed was collected by filtration, washed with water, dried and dissolved in acetone (10 ml.). The solution obtained was acidified with concentrated hydrochloric acid to pH3 to give 1-(4-hydroxybenzyl)-1,2,3,6-tetrahydropyridine hydrochloride (0.6 g.), m.p. 232°-4° C.

후처리

  1. customThe solid which formed
  2. filtrationwas collected by filtration
  3. washwashed with water
  4. customdried
  5. dissolutiondissolved in acetone (10 ml.)
  6. customThe solution obtained

출처 및 근거

ORD 기록
ord-1a3e9270cab846bca29f8a7086ed0548
출처 데이터셋
uspto-grants-1987_02
특허 번호
US04645771

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