Water → HCID 178512607, 화합물

HRID 236647

반응식

HRID 236647 반응식
[N+:1]([C:4]1[CH:13]=[CH:12][CH:11]=[CH:10][C:5]=1[C:6](=O)[CH2:7]Br)([O-:3])=[O:2].[C:14]([NH:17][C:18]([NH2:20])=[S:19])(=[NH:16])[NH2:15].O.[OH-].[Na+]>CN(C)C=O>[NH:17]([C:18]1[S:19][CH:7]=[C:6]([C:5]2[CH:10]=[CH:11][CH:12]=[CH:13][C:4]=2[N+:1]([O-:3])=[O:2])[N:20]=1)[C:14]([NH2:16])=[NH:15]

참가 물질

6

반응물 4

HCID 962WaterHCID 14798Sodium HydroxideHCID 2440252-Bromo-2'-nitroacetophenoneHCID 178513045HCID 178513045, 화합물

생성물 1

HCID 178512607HCID 178512607, 화합물수율 95%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A solution of 16.5 gm of 2-nitro-phenacyl bromide and 7.98 gm of amidinothiourea in 70 ml of dimethylformamide was stirred at room temperature for 16 hours, and then poured into 350 ml of water. The solution was made alkaline with 10% sodium hydroxide, and the solid which separated out after cooling was filtered, washed with water and dried, yielding 16.9 gm of the title compound, m.p. 176°-178° C.

후처리

  1. customthe solid which separated out
  2. temperatureafter cooling
  3. filtrationwas filtered
  4. washwashed with water
  5. customdried

출처 및 근거

ORD 기록
ord-0999f81bbcdc4f8fac59951338ee04e7
출처 데이터셋
uspto-grants-1987_02
특허 번호
US04645841

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