1,2-Dichloroethane → (E)-3-(dimethylamino)-5-(4-hydroxy-3,5-dimethylstyryl)-N-propylbenzamide

HRID 2368879노트

반응식

HRID 2368879 반응식
[CH3:1][N:2]([CH3:26])[C:3]1[CH:4]=[C:5]([CH:9]=[C:10](/[CH:12]=[CH:13]/[C:14]2[CH:19]=[C:18]([CH3:20])[C:17]([O:21]COC)=[C:16]([CH3:25])[CH:15]=2)[CH:11]=1)[C:6](O)=[O:7].C(Cl)CCl.C1C=[N:35][C:34]2N(O)N=N[C:33]=2[CH:32]=1.C(N)CC>CN(C1C=CN=CC=1)C.CN(C=O)C.CCOC(C)=O>[CH3:26][N:2]([CH3:1])[C:3]1[CH:4]=[C:5]([CH:9]=[C:10](/[CH:12]=[CH:13]/[C:14]2[CH:15]=[C:16]([CH3:25])[C:17]([OH:21])=[C:18]([CH3:20])[CH:19]=2)[CH:11]=1)[C:6]([NH:35][CH2:34][CH2:33][CH3:32])=[O:7]

참가 물질

8

반응물 4

HCID 111,2-DichloroethaneHCID 7852PropylamineHCID 181649HOAtHCID 67262210(E)-3-(dimethylamino)-5-(4-(methoxymethoxy)-3,5-dimethylstyryl)benzoic acid

생성물 1

HCID 67256446(E)-3-(dimethylamino)-5-(4-hydroxy-3,5-dimethylstyryl)-N-propylbenzamide

시약·촉매·용매 3

HCID 142844-(Dimethylamino)pyridine촉매HCID 6228Dimethylformamide용매HCID 8857Ethyl Acetate용매

실험 절차

To a solution of 5 (80 mg, 0.225 mmol), EDC (88 mg, 0.45 mmol), HOAT (61.2 mg, 0.45 mmol), and DMAP (5.5 mg, 0.045 mmol) in 2 mL of DMF was added propylamine (37.8 □L, 0.45 mmol) at room temperature. The reaction mixture was stirred overnight (about 18 hours) and diluted with EtOAc. The solution was washed with brine and dried with Na2SO4. The solution was filtered and concentrated.

후처리

  1. washThe solution was washed with brine
  2. dry with materialdried with Na2SO4
  3. filtrationThe solution was filtered
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-2202c4e260094d93a5bcdcb72b704ca9
출처 데이터셋
uspto-grants-2014_04
특허 번호
US08703815B2

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