Hydrochloric Acid → Pyrazole-5-carboxylic acid, 3-phenyl-
반응식
[C:1]1([C:7]2[CH:11]=[C:10]([C:12]([O:14]C)=[O:13])[NH:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Li+].[OH-].Cl>C1COCC1.O>[C:1]1([C:7]2[CH:11]=[C:10]([C:12]([OH:14])=[O:13])[NH:9][N:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1참가 물질
6
실험 절차
To a solution of methyl 3-phenyl-1H-pyrazole-5-carboxylate (6.02 g, 29.8 mmol) in THF and H2O (3:1, 140 mL) was added LiOH (3.42 g, 142.8 mmol) and the mixture was stirred overnight at room temperature. It was poured into 2N HCl solution (150 mL) and extracted with ethyl acetate. After extration, the organic layer was dried over anhydrous sodium sulfate, filtered and concentrated at reduced pressure to afford product (3.2 g, 57.1%): MS (EI) for C10H8N2O2: 189.26 (MH+).
후처리
- extractionextracted with ethyl acetate
- dry with materialAfter extration, the organic layer was dried over anhydrous sodium sulfate
- filtrationfiltered
- concentrationconcentrated at reduced pressure
출처 및 근거
- ORD 기록
- ord-833b35e2f6e74ff492cf0e0deb503280
- 출처 데이터셋
- uspto-grants-2014_04
- 특허 번호
- US08710038B2
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