Formamide → HCID 20277966, 화합물
반응식
Br[CH:2]([C:10]1[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][CH:11]=1)[C:3]([C:5]1[S:6][CH:7]=[CH:8][CH:9]=1)=O.[CH:17]([NH2:19])=O.O.[OH-].[NH4+:22]>C(Cl)(Cl)Cl>[Cl:16][C:13]1[CH:14]=[CH:15][C:10]([C:2]2[N:22]=[CH:17][NH:19][C:3]=2[C:5]2[S:6][CH:7]=[CH:8][CH:9]=2)=[CH:11][CH:12]=1참가 물질
6
실험 절차
A mixture of 35 g of 2-bromo-2-(4-chlorophenyl)-1-(2-thienyl)ethanone and 200 ml of formamide was refluxed under an air condenser for two hours. It was cooled, poured into water and the pH adjusted to 8-9 by adding ammonium hydroxide. Chloroform was added to the solution, and solid separated and was filtered and washed with chloroform; yield 19.3 g. This was recrystallized from dimethylformamide, filtered and washed with acetonitrile; yield 14.7 g, m.p. 244°-245° C.
후처리
- temperaturewas refluxed under an air condenser for two hours
- temperatureIt was cooled
- customseparated
- filtrationwas filtered
- washwashed with chloroform
- customThis was recrystallized from dimethylformamide
- filtrationfiltered
- washwashed with acetonitrile
출처 및 근거
- ORD 기록
- ord-5f0bc647402b411d9a467987d806ffe4
- 출처 데이터셋
- uspto-grants-1979_06
- 특허 번호
- US04159338
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