Diphosgene → 2-Methylimino-3-methyl-5-(2,6-dimethylphenyl)-tetrahydro-1,3,5-thiadiazin-4-one

HRID 237082노트

반응식

HRID 237082 반응식
[CH2:1]=[N:2][C:3]1[C:8]([CH3:9])=[CH:7][CH:6]=[CH:5][C:4]=1[CH3:10].ClC([O:14][C:15](Cl)(Cl)Cl)=O.[CH3:19][NH:20][C:21]([NH:23][CH3:24])=[S:22].[OH-].[Na+]>>[CH3:19][N:20]=[C:21]1[N:23]([CH3:24])[C:15](=[O:14])[N:2]([C:3]2[C:8]([CH3:9])=[CH:7][CH:6]=[CH:5][C:4]=2[CH3:10])[CH2:1][S:22]1

참가 물질

5

반응물 4

HCID 10426DiphosgeneHCID 14798Sodium HydroxideHCID 141978Methanimine, N-(2,6-dimethylphenyl)-HCID 2723631N,N'-Dimethylthiourea

생성물 1

HCID 213147312-Methylimino-3-methyl-5-(2,6-dimethylphenyl)-tetrahydro-1,3,5-thiadiazin-4-one수율 22.5%

실험 절차

Similarly, 2.7 g (0.02 mole) of N-methylene-2,6-dimethylaniline, 2.0 g of trichloromethyl chloroformate, 2.0 g (0.02 mole) of 1,3-dimethylthiourea, and 18 g of a 10% aqueous sodium hydroxide solution were used to obtain 0.6 g (12% yield) of 2-methylimino-3-methyl-5-(2,6-dimethylphenyl)-tetrahydro-1,3,5-thiadiazin-4-one (compound No. 389) of the formula, ##STR179## as a colorless oily substance (nD20 1.5967).

출처 및 근거

ORD 기록
ord-74934cae358f41c5998d8b14ae062304
출처 데이터셋
uspto-grants-1979_06
특허 번호
US04159328

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