Hydrochloric Acid → 1,4-Dimethylpiperazine-2-carboxylic acid
반응식
C([O:3][C:4]([CH:6]1[CH2:11][N:10]([CH3:12])[CH2:9][CH2:8][N:7]1[CH3:13])=[O:5])C.[OH-].[Na+].Cl.CCOCC>CCO>[CH3:13][N:7]1[CH2:8][CH2:9][N:10]([CH3:12])[CH2:11][CH:6]1[C:4]([OH:5])=[O:3]참가 물질
6
실험 절차
Ethyl 1,4-dimethylpiperazin-2-yl carboxylic acid (1.86 g) was dissolved in EtOH (10 mL) and 5M aqueous NaOH (20 mL) added. The mixture was refluxed for 2 hours, allowed to cool, 10M HCl (9.1 mL) added to give pH4 and the mixture evaporated to dryness. The white solid was stirred with MeOH (25 mL), CH2 Cl2 (10 mL) added and the filtrate evaporated to give, after trituration with Et2O, the title compound as a grey solid (761 mg, 48%).
후처리
- temperatureThe mixture was refluxed for 2 hours
- temperatureto cool
- customto give pH4
- customthe mixture evaporated to dryness
- additionadded
- customthe filtrate evaporated
- customto give
출처 및 근거
- ORD 기록
- ord-f758aae1633d43f2bbda2366a51c8c32
- 출처 데이터셋
- uspto-grants-2014_04
- 특허 번호
- US08710224B2
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