Benzoyl Peroxide → Methyl 5-(bromomethyl)pyrazine-2-carboxylate

HRID 2373851

반응식

HRID 2373851 반응식
[CH3:1][O:2][C:3]([C:5]1[CH:10]=[N:9][C:8]([CH3:11])=[CH:7][N:6]=1)=[O:4].C1C(=O)N([Br:19])C(=O)C1.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>C(Cl)(Cl)(Cl)Cl>[CH3:1][O:2][C:3]([C:5]1[CH:10]=[N:9][C:8]([CH2:11][Br:19])=[CH:7][N:6]=1)=[O:4]

참가 물질

5

반응물 3

HCID 7187Benzoyl PeroxideHCID 67184N-bromobutanimideHCID 4650652-Pyrazinecarboxylic acid, 5-methyl-, methyl ester

생성물 1

HCID 21973569Methyl 5-(bromomethyl)pyrazine-2-carboxylate수율 29.6%

시약·촉매·용매 1

HCID 5943Carbon Tetrachloride용매

실험 절차

To a solution of 5-methyl-pyrazine-2-carboxylic acid methyl ester (2.0 g, 13.146 mmol) in CCl4 (25 mL0 was added NBS (2.57 g, 14.461 mmol) and benzoyl peroxide (0.318 g, 1.314 mmol) and the solution was heated at 70 C. for 1 h. Upon cooling to RT, the organic layer was washed with NaHCO3, water, dried (Na2SO4), and concentrated under reduced pressure to give 0.900 g 5-Bromomethyl-pyrazine-2-carboxylic acid methyl ester.

후처리

  1. temperaturethe solution was heated at 70 C
  2. washthe organic layer was washed with NaHCO3, water
  3. dry with materialdried (Na2SO4)
  4. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-943813d9e5094dcda8d8d0ea79ce405a
출처 데이터셋
uspto-grants-2008_12
특허 번호
US07459472B2

연결된 노트

불러오는 중…