Hydrochloric Acid → 4'-(Nonyloxy)[1,1'-biphenyl]-4-carboxylic acid

HRID 2380177

반응식

HRID 2380177 반응식
[OH-].[Na+].[OH:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:18]=[CH:17][C:13]([C:14]([OH:16])=[O:15])=[CH:12][CH:11]=2)=[CH:6][CH:5]=1.Br[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28].Cl>C(O)C>[CH2:20]([O:3][C:4]1[CH:5]=[CH:6][C:7]([C:10]2[CH:18]=[CH:17][C:13]([C:14]([OH:16])=[O:15])=[CH:12][CH:11]=2)=[CH:8][CH:9]=1)[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 127421-BromononaneHCID 14798Sodium Hydroxide2회HCID 3015564'-Hydroxy-4-biphenylcarboxylic acid

생성물 1

HCID 36202634'-(Nonyloxy)[1,1'-biphenyl]-4-carboxylic acid수율 69%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

1.12 g of sodium hydroxide was dissolved in 100 ml of ethyl alcohol. Then, 2.0 g of 4-(4'-hydroxyphenyl) benzoic acid and 2.3 ml of 1-bromononane were added to the solution and refluxed for 19 hours. 50 ml of 10% aqueous sodium hydroxide solution was added and refluxed for another two hours. After cooling, concentrated HCl was dropped into the solution until it was acidic. After filtration and recrystallization from ethyl alcohol gave 2.18 g of pure product (yield 69%).

후처리

  1. temperaturerefluxed for 19 hours
  2. temperaturerefluxed for another two hours
  3. temperatureAfter cooling
  4. filtrationAfter filtration and recrystallization from ethyl alcohol

출처 및 근거

ORD 기록
ord-2326ebe5abc84c5283baac9b3faab9cc
출처 데이터셋
uspto-grants-1994_11
특허 번호
US05366656

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