Hydrochloric Acid → 2,3-Di(9-(Z)-octadecenyl)propan-1ol

HRID 2380441노트

반응식

HRID 2380441 반응식
[CH2:1]([CH:19]([CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30]/[CH:31]=[CH:32]\[CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH3:40])[CH:20]=[O:21])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8]/[CH:9]=[CH:10]\[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18].[BH4-].[Na+].Cl>O1CCCC1.CO.CCOCC>[CH2:1]([CH:19]([CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30]/[CH:31]=[CH:32]\[CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH3:40])[CH2:20][OH:21])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8]/[CH:9]=[CH:10]\[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18]

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 4311764Sodium borohydrideHCID 867437182,3-di(9-(Z)-octadecenyl)propanal

생성물 1

HCID 867437172,3-Di(9-(Z)-octadecenyl)propan-1ol

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 21899815MeOH tetrahydrofuran용매

반응 조건

온도
0 °C

실험 절차

Crude 2,3-di(9-(Z)-octadecenyl) propanal of formula (10) from Preparation 7 (10.0 g, 16.9 mmol) was dissolved in tetrahydrofuran/methanol (1:1, 200 ml) and cooled to 0° C. Sodium borohydride (3.13 g, 85.0 mmol) was added and the mixture was stirred overnight. The solution was acidified with 1N HCl to pH<2, diluted with ether, washed with water, concentrated and column chromatographed (chloroform) to give the title compound as an oil.

후처리

  1. washwashed with water
  2. concentrationconcentrated
  3. customcolumn chromatographed (chloroform)

출처 및 근거

ORD 기록
ord-1b0dbafa68fd48ca8693b50cd1e8e6f0
출처 데이터셋
uspto-grants-1994_11
특허 번호
US05366737

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