Trimethylsilylacetylene → 5-Trimethylsilanylethynyl-1H-indazole

반응식

I[C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][N:6]=[CH:5]2.[CH3:11][Si:12]([C:15]#[CH:16])([CH3:14])[CH3:13]>>[CH3:11][Si:12]([C:15]#[C:16][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][N:6]=[CH:5]2)([CH3:14])[CH3:13]

참가 물질

반응물 2

HCID 66111Trimethylsilylacetylene

HCID 218947395-Iodo-1H-indazole

생성물 1

HCID 579507415-Trimethylsilanylethynyl-1H-indazole수율 46%

실험 절차

In an adaption of GP 8a, 5-Iodo-1H-indazole (0.98 g, 4.02 mmol) was reacted with trimethylsilyl acetylene (0.60 mL, 4.22 mmol) at 90° C. for 5 h to give 395 mg (46%) of pure 5-(trimethylsilyl)ethynyl-1H-indazole.

출처 및 근거

ORD 기록: ord-d97e33d95d5b435aabfb6172bc657155
출처 데이터셋: uspto-grants-2014_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08642611B2

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