Pyridine → 3-Propionylamino-pyrazine-2-carboxylic acid amide

HRID 238240

반응식

HRID 238240 반응식
[NH2:1][C:2]1[C:3]([C:8]([OH:10])=O)=[N:4][CH:5]=[CH:6][N:7]=1.N1C=C[CH:14]=[CH:13][CH:12]=1.[NH3:17].[OH2:18]>CN(C1C=CN=CC=1)C.C(OC(=O)CC)(=O)CC>[C:12]([NH:1][C:2]1[C:3]([C:8]([NH2:17])=[O:10])=[N:4][CH:5]=[CH:6][N:7]=1)(=[O:18])[CH2:13][CH3:14]

참가 물질

6

반응물 3

HCID 1049PyridineHCID 726563-Amino-2-pyrazinecarboxylic acidHCID 12896473Azane;hydrate

생성물 1

HCID 599935133-Propionylamino-pyrazine-2-carboxylic acid amide수율 43%

시약·촉매·용매 2

HCID 142844-(Dimethylamino)pyridine촉매HCID 31263Propionic anhydride용매

실험 절차

A mixture of 3-amino-pyrazine-2-carboxylic acid (20.9 g, 0.15 mol), pyridine (29.6 g, 0.375 mol) and DMAP (1.83 g, 15 mmol) in propionic acid anhydride (100 mL) was stirred at room temperature overnight. The reaction mixture was poured into NH3.H2O (500 mL) partially at 0° C. After stirred for 30 min at 0° C., the precipitated solid was filtered, washed with water, dried in air to give 3-propionylamino-pyrazine-2-carboxylic acid amide as a beige solid (12.4 g, 43%), which was used directly in the next step.

후처리

  1. stirringAfter stirred for 30 min at 0° C.
  2. filtrationthe precipitated solid was filtered
  3. washwashed with water
  4. customdried in air

출처 및 근거

ORD 기록
ord-e462de6e1306463e8024cdb00ecdc717
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08642609B2

연결된 노트

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