Methyl iodide → HCID 68784434, 화합물
반응식
[Br:1][C:2]1[C:10]2[C:9]([C:11]#[N:12])=[CH:8][CH:7]=[CH:6][C:5]=2[NH:4][CH:3]=1.[H-].[Na+].CI.[CH2:17](OC(=O)C)C>CN(C=O)C.CCCCCC>[Br:1][C:2]1[C:10]2[C:9]([C:11]#[N:12])=[CH:8][CH:7]=[CH:6][C:5]=2[N:4]([CH3:17])[CH:3]=1참가 물질
7
반응 조건
- 온도
- 0 °C
실험 절차
3-Bromo-1H-indole-4-carbonitrile (I-146a: 500 mg, 2.272 mmol) was added dropwise to a stirred mixture of NaH (0.218 g, 9.0833 mmol) in dry DMF (15 mL) at 0° C. over a period of 10 minutes. This was followed by the addition of methyl iodide and the resulting mixture was stirred at 0° C. for 2 hours. The reaction was monitored by TLC (10% ethylacetate in hexane). The reaction mixture was quenched with ice water; the precipitate formed was collected and dried to afford 0.400 g of the crude product.
후처리
- customThe reaction mixture was quenched with ice water
- customthe precipitate formed
- customwas collected
- customdried
출처 및 근거
- ORD 기록
- ord-ef19978332fa45d482d618f37b8d2623
- 출처 데이터셋
- uspto-grants-2012_09
- 특허 번호
- US08263635B2
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