Hydrochloric Acid → Pyrimidine-2,4-dicarboxylic acid

HRID 2384096노트

반응식

HRID 2384096 반응식
[N:1]1[CH:6]=[CH:5][C:4]([C:7]([O:9]CC)=[O:8])=[N:3][C:2]=1[C:12]([O:14]CC)=[O:13].[OH-].[Na+].Cl>CO>[N:1]1[CH:6]=[CH:5][C:4]([C:7]([OH:9])=[O:8])=[N:3][C:2]=1[C:12]([OH:14])=[O:13]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 66701935Diethyl pyrimidine-2,4-dicarboxylate

생성물 1

HCID 45117348Pyrimidine-2,4-dicarboxylic acid

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Next, to a stirred solution of diethyl pyrimidine-2,4-dicarboxylate (130 mg, 0.58 mmol) in MeOH (3 mL) is added 1N NaOH (2 mL) and the mixture is stirred at room temperature for 3 hours. The solution is carefully acidified with 1N HCl and the solvent is removed under reduced pressure to give pyrimidine-2,4-dicarboxylic acid. This is used as is in subsequent reactions.

후처리

  1. customthe solvent is removed under reduced pressure

출처 및 근거

ORD 기록
ord-733ed67d8a2241ddb3d659abb439f21d
출처 데이터셋
uspto-grants-2012_09
특허 번호
US08263629B2

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