Potassium Cyanide → 2-(4-((2-Amino-4-chloro-6-methylpyrimidin-5-yl)methyl)-3-fluorophenyl)acetonitrile

HRID 2387835

반응식

HRID 2387835 반응식
[C-:1]#[N:2].[K+].[Cl:4][C:5]1[C:10]([CH2:11][C:12]2[CH:17]=[CH:16][C:15]([CH2:18]Cl)=[CH:14][C:13]=2[F:20])=[C:9]([CH3:21])[N:8]=[C:7]([NH2:22])[N:6]=1>CS(C)=O.CN(C=O)C.CCOC(C)=O>[NH2:22][C:7]1[N:6]=[C:5]([Cl:4])[C:10]([CH2:11][C:12]2[CH:17]=[CH:16][C:15]([CH2:18][C:1]#[N:2])=[CH:14][C:13]=2[F:20])=[C:9]([CH3:21])[N:8]=1

참가 물질

6

반응물 2

HCID 9032Potassium CyanideHCID 866334044-Chloro-5-(4-(chloromethyl)-2-fluorobenzyl)-6-methylpyrimidin-2-amine

생성물 1

HCID 866334052-(4-((2-Amino-4-chloro-6-methylpyrimidin-5-yl)methyl)-3-fluorophenyl)acetonitrile

시약·촉매·용매 3

HCID 679Dimethyl Sulfoxide용매HCID 6228Dimethylformamide용매HCID 8857Ethyl Acetate용매

실험 절차

Potassium cyanide (0.056 g) was added to a stirred solution of the product from step (ii) (0.13 g) in DMSO (1 mL) and DMF (1 mL). The mixture was stirred at rt for 15 h and then diluted with EtOAc (10 mL). The organic phase was washed with water and brine then dried, filtered and evaporated to give the subtitle compound, 0.12 g.

후처리

  1. washThe organic phase was washed with water and brine
  2. customthen dried
  3. filtrationfiltered
  4. customevaporated

출처 및 근거

ORD 기록
ord-8d0c87902e204e5db037e8e0f1c279e0
출처 데이터셋
uspto-grants-2012_09
특허 번호
US08268990B2

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