4-Methoxyphenylacetic Acid → 2-(3-((2-Amino-4-methyl-6-(pentylamino)pyrimidin-5-yl)methyl)-4-methoxyphenyl)acetic acid

HRID 2387870노트

반응식

HRID 2387870 반응식
[NH2:1][C:2]1[N:7]=[C:6]([CH3:8])[C:5]([CH2:9]O)=[C:4]([NH:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16])[N:3]=1.[CH3:17][O:18][C:19]1[CH:24]=[CH:23][C:22]([CH2:25][C:26]([OH:28])=[O:27])=[CH:21][CH:20]=1>Cl>[NH2:1][C:2]1[N:7]=[C:6]([CH3:8])[C:5]([CH2:9][C:24]2[CH:23]=[C:22]([CH2:25][C:26]([OH:28])=[O:27])[CH:21]=[CH:20][C:19]=2[O:18][CH3:17])=[C:4]([NH:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16])[N:3]=1

참가 물질

4

반응물 2

HCID 76904-Methoxyphenylacetic AcidHCID 68418011(2-Amino-4-methyl-6-(pentylamino)pyrimidin-5-yl)methanol

생성물 1

HCID 684129432-(3-((2-Amino-4-methyl-6-(pentylamino)pyrimidin-5-yl)methyl)-4-methoxyphenyl)acetic acid

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

To the product from step (iii) (0.8 g) in 1M aq HCl (20 ml), 4-methoxyphenylacetic acid (1.8 g) was added and heated under reflux for 48 h. The solvent was evaporated and the residue purified by SCX then by RPHPLC to give the subtitle compound, 164 mg.

후처리

  1. temperatureheated
  2. temperatureunder reflux for 48 h
  3. customThe solvent was evaporated
  4. customthe residue purified by SCX

출처 및 근거

ORD 기록
ord-c124e5efbc774b818ab2ef702b6b7f99
출처 데이터셋
uspto-grants-2012_09
특허 번호
US08268990B2

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