Hydrochloric Acid → 2-Furanacrylic acid

HRID 2389863

반응식

HRID 2389863 반응식
[CH:1]1[CH:5]=[C:4]([CH:6]=O)[O:3][CH:2]=1.C(O)(=O)[CH2:9][C:10]([OH:12])=[O:11].N1CCCCC1.Cl>N1C=CC=CC=1.O>[O:3]1[CH:2]=[CH:1][CH:5]=[C:4]1/[CH:6]=[CH:9]/[C:10]([OH:12])=[O:11]

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 867Malonic AcidHCID 7362FurfuralHCID 8082Piperidine

생성물 1

HCID 6434022-Furanacrylic acid수율 92%

시약·촉매·용매 2

HCID 962Water용매HCID 1049Pyridine용매

반응 조건

온도
100 °C

실험 절차

To a mixture of 2-furfural (500 g, 5.20 mol) and malonic acid (595 g, 5.72 mol) in pyridine (500 mL) was added piperidine (50 mL, 0.505 mol) at room temperature, and the mixture was stirred at 100° C. for 3 hr. The reaction solution was poured into water (1 L) and acidified with 6M hydrochloric acid. The resulting precipitate was collected by filtration to give the title compound (660 g, yield 92%).

후처리

  1. filtrationThe resulting precipitate was collected by filtration

출처 및 근거

ORD 기록
ord-f4f5782bb6ab4fe5b912f3315f5b6e9d
출처 데이터셋
uspto-grants-2012_09
특허 번호
US08273761B2

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