Water → 2,6-Dibromo-3-methoxypyridine

HRID 2391743

반응식

HRID 2391743 반응식
[Br:1][C:2]1[C:7]([OH:8])=[CH:6][CH:5]=[C:4]([Br:9])[N:3]=1.[C:10]([O-])([O-])=O.[K+].[K+].CI.O>CS(C)=O>[Br:1][C:2]1[C:7]([O:8][CH3:10])=[CH:6][CH:5]=[C:4]([Br:9])[N:3]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 810772,6-Dibromopyridin-3-ol

생성물 1

HCID 113346372,6-Dibromo-3-methoxypyridine

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

실험 절차

To a solution of 52.5 g 2,6-dibromopyridin-3-ol (example E1) in 90 ml DMSO were added 26.2 g K2CO3 and 43.8 ml methyl iodide and the reaction mixture was stirred under reflux for one hour. The mixture was allowed to cool down to room temperature and poured into 1 l of water and stirred for 3 h at 80° C. After cooling to room temperature the resulting solid was filtered, the filter cake was washed with ice cold water and dried under vacuum to yield the title compound.

후처리

  1. temperatureunder reflux for one hour
  2. stirringstirred for 3 h at 80° C
  3. temperatureAfter cooling to room temperature the resulting solid
  4. filtrationwas filtered
  5. washthe filter cake was washed with ice cold water
  6. customdried under vacuum

출처 및 근거

ORD 기록
ord-e5beefebb0a44d4eaeed350d335a5d50
출처 데이터셋
uspto-grants-2012_09
특허 번호
US08273890B2

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