Propylamine → 2,4-dichloro-N-propylbenzenesulfonamide

HRID 23925

반응식

HRID 23925 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[S:9](Cl)(=[O:11])=[O:10].[CH2:13]([NH2:16])[CH2:14][CH3:15]>C(O)CCC>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[S:9](=[O:11])(=[O:10])[NH:16][CH2:13][CH2:14][CH3:15]

참가 물질

4

반응물 2

HCID 7852PropylamineHCID 204419Benzenesulfonyl chloride, 2,4-dichloro-

생성물 1

HCID 220249232,4-dichloro-N-propylbenzenesulfonamide

시약·촉매·용매 1

HCID 2631-Butanol용매

실험 절차

2,4-Dichlorobenzenesulphonyl chloride (500 mg 2.1 mmol) and 1-propylamine (0.2 ml, 2.4 mmol) in n-butanol (10 ml) was heated at reflux for 48 hour. The volatiles were removed by evaporation and the residue triturated with ether and the product collected by filtration to give the title compound. NMR: 0.78 (t, 3H), 1.35 (q, 2H), 2.79 (t, 2H), 7.60 (dd, 1H), 7.84 (d, 1H), 7.92 (d, 2H)

후처리

  1. temperatureat reflux for 48 hour
  2. customThe volatiles were removed by evaporation
  3. customthe residue triturated with ether
  4. filtrationthe product collected by filtration

출처 및 근거

ORD 기록
ord-37be21b4eed649eda844f890b04888da
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06855719B1

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