Methyl iodide → HCID 18979095, 화합물

HRID 2393095노트

반응식

HRID 2393095 반응식
[Br:1][C:2]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[C:8]2[C:3]=1[CH:4]=[CH:5][C:6]([NH:14][C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])=[N:7]2.O1CCC[CH2:23]1.[H-].[Na+].IC>C(OCC)(=O)C>[Br:1][C:2]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[C:8]2[C:3]=1[CH:4]=[CH:5][C:6]([N:14]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH3:23])=[N:7]2

참가 물질

6

반응물 4

HCID 6328Methyl iodideHCID 8028TetrahydrofuranHCID 24758Sodium hydrideHCID 18979069HCID 18979069, 화합물

생성물 1

HCID 18979095HCID 18979095, 화합물

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

5-Bromo-2-t-butyloxycarbonylamino-8-Methoxyquinoline (1.21 g) and tetrahydrofuran (20 ml) were combined at room temperature under a nitrogen atmosphere. Sodium hydride (60% dispersion in oil) (164 mg) was added and the reaction mixture stirred for 2 h whilst effervescence occurred and a yellow colour appeared. Iodomethane (0.43 ml) was then added and stirring was continued for 2 h after which time the reaction was diluted with ethyl acetate (100 ml), washed successively with water, saturated aqueous sodium bicarbonate and brine, then dried (magnesium sulphate) and evaporated in vacuo to give the title compound (1.1 g) as a yellow solid.

후처리

  1. customwere combined at room temperature under a nitrogen atmosphere
  2. stirringstirring
  3. waitwas continued for 2 h
  4. washwashed successively with water, saturated aqueous sodium bicarbonate and brine
  5. dry with materialdried (magnesium sulphate)
  6. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-8da48e0f22ce4333aa4ab2cfb937ba4a
출처 데이터셋
uspto-grants-1998_09
특허 번호
US05804588

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