Hydrochloric Acid → HCID 7440508, 화합물

HRID 2393101노트

반응식

HRID 2393101 반응식
C[O:2][C:3](=[O:27])[C@H:4]([NH:15][S:16]([C:19]1[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[CH:21][CH:20]=1)(=[O:18])=[O:17])[CH2:5][C:6]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[NH:8][CH:7]=1.[OH-].[Na+].Cl>C(O)C>[CH3:26][O:25][C:22]1[CH:23]=[CH:24][C:19]([S:16]([NH:15][C@H:4]([CH2:5][C:6]2[C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[NH:8][CH:7]=2)[C:3]([OH:27])=[O:2])(=[O:17])=[O:18])=[CH:20][CH:21]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 6977080HCID 6977080, 화합물

생성물 1

HCID 7440508HCID 7440508, 화합물수율 93%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To 1.3 mmol of 2(R)-[(4-methoxybenzenesulfonyl)amino]-3-(3-indolyl)-propanoic acid methyl ester suspended in 15 mL of ethanol is added 5 mL of aqueous 2.5M sodium hydroxide. The solid suspension dissolved, and is allowed to stir at ambient temperature overnight. The mixture is acidified with aqueous 10% HCl and extracted with ethyl acetate. The organic phase is washed with brine and dried over sodium sulfate. It is concentrated to afford 0.45 g (93%) of a white solid,

후처리

  1. dissolutionThe solid suspension dissolved
  2. extractionextracted with ethyl acetate
  3. washThe organic phase is washed with brine
  4. dry with materialdried over sodium sulfate
  5. concentrationIt is concentrated

출처 및 근거

ORD 기록
ord-16035cd2f2244980a445b7fe7e8c4424
출처 데이터셋
uspto-grants-1998_09
특허 번호
US05804593

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