Chloroform → 2-(1-Hydroxyiminoethyl)-4-[4-(2-hydroxyethyl)piperazin-1-ylmethyl]phenol

HRID 23936노트

반응식

HRID 23936 반응식
Cl.[NH2:2][OH:3].C(=O)(O)[O-].[Na+].[C:9]([C:12]1[CH:17]=[C:16]([CH2:18][N:19]2[CH2:24][CH2:23][N:22]([CH2:25][CH2:26][OH:27])[CH2:21][CH2:20]2)[CH:15]=[CH:14][C:13]=1[OH:28])(=O)[CH3:10].C(Cl)(Cl)Cl>O.CO>[OH:3][N:2]=[C:9]([C:12]1[CH:17]=[C:16]([CH2:18][N:19]2[CH2:24][CH2:23][N:22]([CH2:25][CH2:26][OH:27])[CH2:21][CH2:20]2)[CH:15]=[CH:14][C:13]=1[OH:28])[CH3:10]

참가 물질

7

반응물 4

HCID 6212ChloroformHCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium BicarbonateHCID 98604522-Acetyl-4-[4-(2-hydroxyethyl)piperazin-1-yl-methyl]phenol

생성물 1

HCID 1359919502-(1-Hydroxyiminoethyl)-4-[4-(2-hydroxyethyl)piperazin-1-ylmethyl]phenol수율 81%

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

반응 조건

온도
65 °C

실험 절차

Hydroxylamine hydrochloride (63 mg, 0.9 mmol) and sodium bicarbonate (76 mg, 0.9 mmol) were dissolved in distilled water (1 ml). 2-Acetyl-4-[4-(2-hydroxyethyl)-piperazin-1-yl-methyl]phenol (85 mg, 0.3 mmol) in absolute methanol (2 ml) was added and the reaction mixture was stirred at 65° C. for 24 h. CHCl3 (20 ml) was then added, the organic phase washed with water followed by brine, dried over Na2SO4, filtered and evaporated to obtain the title product (52 mg, 81%).

후처리

  1. washthe organic phase washed with water
  2. dry with materialdried over Na2SO4
  3. filtrationfiltered
  4. customevaporated

출처 및 근거

ORD 기록
ord-16df7836f55644e0b2139ea2dbbfac49
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06855711B1

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