Acetic Acid → 1-Boc-4-[2-(4-pyridinyl)ethyl]piperazine

HRID 23960

반응식

HRID 23960 반응식
[C:1]([N:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].[CH:14]([C:16]1[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=1)=[CH2:15].C(O)(=O)C>C(O)C>[C:1]([N:8]1[CH2:9][CH2:10][N:11]([CH2:15][CH2:14][C:16]2[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=2)[CH2:12][CH2:13]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2]

참가 물질

5

반응물 3

HCID 176Acetic AcidHCID 75024-VinylpyridineHCID 143452tert-Butyl piperazine-1-carboxylate

생성물 1

HCID 223216311-Boc-4-[2-(4-pyridinyl)ethyl]piperazine수율 46.3%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

1-Boc-piperazine (4.0 g, 21.5 mmol), 4-vinylpyridine (2.94 g, 27.9 mmol), and acetic acid (1.29 g, 21.5 mmol) were mixed in ethanol and heated to reflux for 48 h. The mixture was cooled to room temperature and concentrated under vacuum to provide 1-Boc-4-[2-(4-pyridinyl)ethyl]-piperazine (2.9 g, 45%) as an off white solid. The product was used without further purification.

후처리

  1. temperatureheated
  2. temperatureto reflux for 48 h
  3. concentrationconcentrated under vacuum

출처 및 근거

ORD 기록
ord-0cbde3c2a82a4113837f2babf03f86ec
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06855715B1

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