Hydrochloric Acid → 4,6-Dibromo-5-hydroxypyridine-2-carboxylic acid
반응식
[OH-].[Na+].C[O:4][C:5]([C:7]1[CH:12]=[C:11]([Br:13])[C:10]([OH:14])=[C:9]([Br:15])[N:8]=1)=[O:6].Cl>O>[Br:13][C:11]1[C:10]([OH:14])=[C:9]([Br:15])[N:8]=[C:7]([C:5]([OH:6])=[O:4])[CH:12]=1참가 물질
5
실험 절차
A solution of 0.5 g sodium hydroxide in 15 ml of water was added to 2 g of 4,6-dibromo-5-hydroxy-2-pyridine-carboxylic acid methyl ester and refluxed for 2 hours. The product was isolated, by cooling and acidifying with concentrated hydrochloric acid, in 53% yield; m.p. 195° -197° C.
후처리
- temperaturerefluxed for 2 hours
- customThe product was isolated
- temperatureby cooling
출처 및 근거
- ORD 기록
- ord-b806ab5a3fed4ab3871c1a73a4419a67
- 출처 데이터셋
- uspto-grants-1977_05
- 특허 번호
- US04025333
반응 노트
불러오는 중…