Sodium Hydroxide → HCID 54527366, 화합물

HRID 2399412노트

반응식

HRID 2399412 반응식
[CH:1]1([CH2:4][O:5][C:6]2[CH:7]=[C:8]([CH:11]=[CH:12][C:13]=2[O:14][CH:15]([F:17])[F:16])[CH:9]=[O:10])[CH2:3][CH2:2]1.[BH4-].[Na+].[OH-].[Na+]>C(O)C>[CH:1]1([CH2:4][O:5][C:6]2[CH:7]=[C:8]([CH:11]=[CH:12][C:13]=2[O:14][CH:15]([F:16])[F:17])[CH2:9][OH:10])[CH2:3][CH2:2]1

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 4311764Sodium borohydrideHCID 189736983-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzaldehyde

생성물 1

HCID 54527366HCID 54527366, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Crude 3-cyclopropylmethoxy-4-difluoromethoxybenzaldehyde (26.4 g) in absolute ethanol (200 mL) was treated with sodium borohydride (8.23 g, 217 mmol) under an argon atmosphere at room temperature for 0.33 h. Ten percent aqueous sodium hydroxide (150 mL) was added, the ethanol was removed in vacuo and the aqueous residue was extracted three times with ether. The organic extract was washed twice with brine, was dried (sodium sulfate), was filtered and was evaporated to a pale yellow oil (24.4 g).

후처리

  1. customthe ethanol was removed in vacuo
  2. extractionthe aqueous residue was extracted three times with ether
  3. extractionThe organic extract
  4. washwas washed twice with brine
  5. dry with materialwas dried (sodium sulfate)
  6. filtrationwas filtered
  7. customwas evaporated to a pale yellow oil (24.4 g)

출처 및 근거

ORD 기록
ord-e3dfbd6fd8474059be1ff5293a992c8a
출처 데이터셋
uspto-grants-1995_09
특허 번호
US05449686

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