N-bromobutanimide → 5-Bromo-6-chloro-2-methanesulfinylpyrimidin-4-amine

HRID 2401160

반응식

HRID 2401160 반응식
[Br:1]N1C(=O)CCC1=O.[Cl:9][C:10]1[N:15]=[C:14]([S:16]([CH3:18])=[O:17])[N:13]=[C:12]([NH2:19])[CH:11]=1>CN(C=O)C>[Br:1][C:11]1[C:12]([NH2:19])=[N:13][C:14]([S:16]([CH3:18])=[O:17])=[N:15][C:10]=1[Cl:9]

참가 물질

4

반응물 2

HCID 67184N-bromobutanimideHCID 15563630HCID 15563630, 화합물

생성물 1

HCID 866770165-Bromo-6-chloro-2-methanesulfinylpyrimidin-4-amine수율 81%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

11.2 g (62.6 mmol) de N-bromosuccinimide were slowly added to a cooled suspension of 10 g (52.2 mmol) 6-chloro-2-(methylsulfinyl)pyrimidine-4-amine in 130 ml of DMF. After 50 minutes stirring at room temperature the precipitate was filtered washed with cool DMF, several times with cool water and dried in vacuum. There was obtained 11.4 g (81%) of a white solid.

후처리

  1. filtrationwas filtered
  2. washwashed with cool DMF, several times with cool water
  3. customdried in vacuum

출처 및 근거

ORD 기록
ord-ab2294b0b0e240c9a93440f63ec30081
출처 데이터셋
uspto-grants-2014_08
특허 번호
US08796284B2

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