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Hydrochloric Acid → HCID 56593458, 화합물

HRID 240261
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HRID 240261 반응식
[CH:1]([C:4]1[CH:5]=[C:6]([CH:29]=[CH:30][CH:31]=1)[O:7][CH:8]([CH3:28])[C:9]([NH:11][C:12]1[CH:17]=[CH:16][C:15]([CH:18]([C:25]#[C:26][CH3:27])[CH2:19][C:20]([O:22]CC)=[O:21])=[CH:14][CH:13]=1)=[O:10])([CH3:3])[CH3:2].O.Cl>C(#N)C.[OH-].[Na+]>[CH:1]([C:4]1[CH:5]=[C:6]([CH:29]=[CH:30][CH:31]=1)[O:7][CH:8]([CH3:28])[C:9]([NH:11][C:12]1[CH:13]=[CH:14][C:15]([CH:18]([C:25]#[C:26][CH3:27])[CH2:19][C:20]([OH:22])=[O:21])=[CH:16][CH:17]=1)=[O:10])([CH3:2])[CH3:3]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 58031811HCID 58031811, 화합물

생성물 1

HCID 56593458HCID 56593458, 화합물수율 37%

시약·촉매·용매 2

HCID 6342Acetonitrile용매HCID 14798Sodium Hydroxide용매

실험 절차

A solution of 156 mg of ethyl 3-{4-[2-(3-isopropylphenoxy)propionylamino]phenyl}-hex-4-ynoate in 7 ml of acetonitrile and 7 ml of 1 N NaOH (aq) was stirred at room temperature for 18 h. The reaction mixture was admixed with water and adjusted to pH=1 with 1 N HCl (aq) and then extracted with ethyl acetate. The organic phase was dried over MgSO4, filtered and concentrated under high vacuum. This gave 109 mg of 3-{4-[2-(3-isopropylphenoxy)propionylamino]phenyl}hex-4-ynoic acid in 37% yield over the two stages.

후처리

  1. extractionextracted with ethyl acetate
  2. dry with materialThe organic phase was dried over MgSO4
  3. filtrationfiltered
  4. concentrationconcentrated under high vacuum

출처 및 근거

ORD 기록
ord-456a7fcf2e9e4f659d704775ca95567a
출처 데이터셋
uspto-grants-2014_02
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08648038B2

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