Methyl iodide → 5-Chloro-2-heptyl-1-methyl-1H-indole
반응식
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17])=[CH:5]2.[OH-].[K+].I[CH3:21]>CS(C)=O>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH3:21])[C:6]([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17])=[CH:5]2참가 물질
5
실험 절차
To the solution of 5-chloro-2-heptyl-1H-indole in DMSO was added KOH at RT and was stirred for 30 minutes. Then to this mixture, iodomethane was added and stirred for 3 hours. The reaction was quenched with saturated ammonium chloride solution and extracted with ethyl acetate. The product, 5-chloro-2-heptyl-1-methyl-1H-indole was purified by column chromatography.
후처리
- stirringstirred for 3 hours
- customThe reaction was quenched with saturated ammonium chloride solution
- extractionextracted with ethyl acetate
- customThe product, 5-chloro-2-heptyl-1-methyl-1H-indole was purified by column chromatography
출처 및 근거
- ORD 기록
- ord-baac91965f8145faa0e5077a0881266a
- 출처 데이터셋
- uspto-grants-2014_08
- 특허 번호
- US08809382B2
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