2-chloro-5-nitropyridin-4-amine → 6-Chloropyridine-3,4-diamine

HRID 2409047

반응식

HRID 2409047 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([NH2:8])[C:5]([N+:9]([O-])=O)=[CH:4][N:3]=1>CCOC(C)=O.[Ni]>[Cl:1][C:2]1[N:3]=[CH:4][C:5]([NH2:9])=[C:6]([NH2:8])[CH:7]=1

참가 물질

4

반응물 1

HCID 109100582-chloro-5-nitropyridin-4-amine

생성물 1

HCID 8171336-Chloropyridine-3,4-diamine수율 107.4%

시약·촉매·용매 2

HCID 935Nickel촉매HCID 8857Ethyl Acetate용매

실험 절차

To a solution of 2-chloro-5-nitropyridin-4-amine (4.50 g, 25.93 mmol) in EtOAc (100 mL) was added Raney nickel (0.45 g) followed by stirring under hydrogen at RT for 2 h. The reaction mixture was filtered and the filtrate concentrated under reduced pressure to afford 4.00 g (ca. 100%) of crude 6-chloropyridine-3,4-diamine as yellow oil. MS (ESI): m/z=144.3 [M+1]+.

후처리

  1. filtrationThe reaction mixture was filtered
  2. concentrationthe filtrate concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-6be8b6661d27469f9649a4b31d83a784
출처 데이터셋
uspto-grants-2014_08
특허 번호
US08815877B2

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