Acetyl chloride → N-[(5-Acetyl-2-thienyl)methyl]acetamide

HRID 2413891노트

반응식

HRID 2413891 반응식
[C:1]([NH:4][CH2:5][C:6]1[S:7][CH:8]=[CH:9][CH:10]=1)(=[O:3])[CH3:2].[C:11](Cl)(=[O:13])[CH3:12].[Cl-].[Al+3].[Cl-].[Cl-]>ClC(Cl)C>[C:1]([NH:4][CH2:5][C:6]1[S:7][C:8]([C:11](=[O:13])[CH3:12])=[CH:9][CH:10]=1)(=[O:3])[CH3:2]

참가 물질

5

반응물 3

HCID 6367Acetyl chlorideHCID 30617N-[(thiophen-2-yl)methyl]acetamideHCID 6451240Aluminum(III) Chloride

생성물 1

HCID 7131592N-[(5-Acetyl-2-thienyl)methyl]acetamide

시약·촉매·용매 1

HCID 63651,1-Dichloroethane용매

반응 조건

온도
10 °C

실험 절차

To a solution of 40 g of 2-acetylaminomethylthiophene and 30.3 g of acetylchloride in 600 ml of dichloroethane is added a small portion of 76.3 g of anhydrous aluminum chloride under cooling at 5°-10° C. After the mixture is stirred at 10° C. for 30 minutes and poured into ice-cold water, the precipitated crystals are collected by filtration to give 2-acetylaminomethyl-5-acetylthiophene, melting F- at 129°-130° C.

후처리

  1. temperatureunder cooling at 5°-10° C
  2. additionpoured into ice-cold water
  3. filtrationthe precipitated crystals are collected by filtration

출처 및 근거

ORD 기록
ord-6a711cea372044ecb528741d3b543c97
출처 데이터셋
uspto-grants-1988_01
특허 번호
US04720493

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