Ammonia → 8-Bromo-2-chloroquinoline

HRID 2415891

반응식

HRID 2415891 반응식
[Br:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[NH:10][C:9](=O)[CH:8]=[CH:7]2.O.N.P(Cl)(Cl)([Cl:17])=O>>[Br:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[C:9]([Cl:17])[CH:8]=[CH:7]2

참가 물질

5

반응물 4

HCID 222AmmoniaHCID 962WaterHCID 24813Phosphorus oxychlorideHCID 109330948-Bromo-1,2-dihydroquinolin-2-one

생성물 1

HCID 109557558-Bromo-2-chloroquinoline

실험 절차

A suspension of 2.8 g (12.49 mmol) of 8-bromo-1H-quinoline-2-one in 20 ml of phosphorus oxychloride is refluxed for 90 minutes and the reaction mixture is cooled and then added dropwise to 200 ml of water. The aqueous solution is made basic with concentrated ammonia solution, the precipitate formed is filtered off and washed with water.

후처리

  1. temperatureis refluxed for 90 minutes
  2. temperaturethe reaction mixture is cooled
  3. customthe precipitate formed
  4. filtrationis filtered off
  5. washwashed with water

출처 및 근거

ORD 기록
ord-5a0e0f02466448bca837c883e86815a5
출처 데이터셋
uspto-grants-2004_11
특허 번호
US06821967B2

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