Hydrochloric Acid → 2-Sulfamoyl-1,3-benzothiazol-6-yl dimethylcarbamate

HRID 2418290노트

반응식

HRID 2418290 반응식
[OH:1][C:2]1[CH:14]=[CH:13][C:5]2[N:6]=[C:7]([S:9]([NH2:12])(=[O:11])=[O:10])[S:8][C:4]=2[CH:3]=1.[CH3:15][N:16]([CH3:20])[C:17](Cl)=[O:18].Cl>CN(C)C1C=CN=CC=1.N1C=CC=CC=1>[CH3:15][N:16]([CH3:20])[C:17](=[O:18])[O:1][C:2]1[CH:14]=[CH:13][C:5]2[N:6]=[C:7]([S:9](=[O:11])(=[O:10])[NH2:12])[S:8][C:4]=2[CH:3]=1

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 6598Dimethylcarbamoyl Chloride2회HCID 68521296-Hydroxy-1,3-benzothiazole-2-sulfonamide

생성물 1

HCID 444619572-Sulfamoyl-1,3-benzothiazol-6-yl dimethylcarbamate수율 76,325.203%

시약·촉매·용매 2

HCID 142844-(Dimethylamino)pyridine촉매HCID 1049Pyridine용매

실험 절차

To a stirred solution of 6-hydroxy-2-benzothiazolesulfonamide (2.3 g, 0.01 mole) and 4-dimethylaminopyridine (200 mg) in pyridine (25 ml) was added dimethylcarbamoyl chloride (0.95 ml, 0.01 mmole). After stirring for 18 hours additional dimethylcarbamoyl chloride (1.5 ml) was added and stirring was continued for 18 hours. The reaction mixture was poured into ice water and excess hydrochloric acid to give 2.3 g of (2-sulfamoyl-6-benzothiazolyl) N,N-dimethylcarbamate which melts at 208°-209° C. after recrystallization from 2-propanol.

후처리

  1. additionwas added

출처 및 근거

ORD 기록
ord-33a5ebb4954e46929f019ad73b6f61d9
출처 데이터셋
uspto-grants-1984_09
특허 번호
US04472417

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