Benzenepropanoic acid → 3-[4-(Chloroacetyl)phenyl]propionic acid

HRID 2419368노트

반응식

HRID 2419368 반응식
[C:1]1([CH2:7][CH2:8][C:9]([OH:11])=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cl:12][CH2:13][C:14](Cl)=[O:15].[Cl-].[Al+3].[Cl-].[Cl-].Cl>C(Cl)CCl>[Cl:12][CH2:13][C:14]([C:4]1[CH:5]=[CH:6][C:1]([CH2:7][CH2:8][C:9]([OH:11])=[O:10])=[CH:2][CH:3]=1)=[O:15]

참가 물질

6

반응물 4

HCID 107Benzenepropanoic acidHCID 313Hydrochloric AcidHCID 6577Chloroacetyl chlorideHCID 6451240Aluminum(III) Chloride

생성물 1

HCID 203155713-[4-(Chloroacetyl)phenyl]propionic acid

시약·촉매·용매 1

HCID 111,2-Dichloroethane용매2회

실험 절차

A solution of 3-phenylpropionic acid (50g.) in ethylenedichloride (200ml.) was added over 1 hour to a stirred mixture of chloroacetyl chloride (37.7g.) and aluminum chloride (48.9g.) in ethylene dichloride (550ml.) at room temperature. The resulting mixture was stirred for 1 hour and was then poured cautiously onto a mixture of ice (2kg.) and concentrated hydrochloric acid (50ml.). After stirring for a further 16 hours, the crude product was separated by filtration and recrystallised from water to give 3-[4-(chloroacetyl)phenyl]propionic acid, m.p. 151°-153° C.

후처리

  1. stirringAfter stirring for a further 16 hours
  2. customthe crude product was separated by filtration
  3. customrecrystallised from water

출처 및 근거

ORD 기록
ord-8f7c1a316680455da42061af6cb0f46d
출처 데이터셋
uspto-grants-1978_08
특허 번호
US04105790

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