반응식
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][NH:17][C:18]([C:20]2([C:24]3[CH:29]=[CH:28][C:27]([Cl:30])=[CH:26][C:25]=3[O:31][CH3:32])[CH2:23][CH2:22][CH2:21]2)=O)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.P(Cl)(Cl)(Cl)=O>>[CH2:1]([O:8][C:9]1[CH:14]=[C:13]2[C:12]([CH2:15][CH2:16][N:17]=[C:18]2[C:20]2([C:24]3[CH:29]=[CH:28][C:27]([Cl:30])=[CH:26][C:25]=3[O:31][CH3:32])[CH2:23][CH2:22][CH2:21]2)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1참가 물질
3
실험 절차
7-(Benzyloxy)-1-[1-(4-chloro-2-methoxyphenyl)cyclobutyl]-3,4-dihydroisoquinoline was prepared analogously to example 65 using N-{2-[4-(benzyloxy)phenyl]ethyl}-1-(4-chloro-2-methoxyphenyl)cyclobutanecarboxamide (1.1 g, 2.445 mmol) and phosphoric trichloride (3.75 g, 24.45 mmol). Yield: 65 mg (0.15 mmol, 6%).
출처 및 근거
- ORD 기록
- ord-7868f003e6fd4ce9ac2d5051bef428d1
- 출처 데이터셋
- uspto-grants-2014_02
- 특허 번호
- US08653100B2
연결된 노트
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